Blog

MTX Risk Calculator: my PharmacoFlash at IATDMCT 2026

A written version of my three-minute talk on full Bayesian risk predictions after high-dose methotrexate, plus the discussion afterwards.

Marian Klose

Oct 6, 2026

Practical foundations for agentic workflows in pharmacometrics

A written version of my ISoP AI/ML SIG presentation.

Marian Klose

Sep 21, 2026

Building a Human-in-the-Loop LLM Agent Workflow for Pharmacometrics

llm

agentic workflows

human in the loop

Part 1: A Hello World Example with LangGraph

Marian Klose

May 25, 2026

Using ChatGPT from the command line

ChatGPT

openai

LLM

Supercharging LLMs by building agentic workflows.

Marian Klose

Jul 31, 2025

Reproducing NONMEM’s MAP estimation in R

How to perform Bayesian MAP estimation yourself using R and why you should care.

Marian Klose

Mar 31, 2025

My attempt to understand the NLME estimation algorithm behind NONMEM

Estimation

NONMEM

Laplacian

An R-based reproduction using straight-line equations.

Marian Klose

Jan 11, 2025

Expressing RUV as $THETA in NONMEM

RUV

Error

NONMEM

Have you ever been confused why some people use the $THETA block to code their RUV in NONMEM? You are not alone!

Marian Klose

Dec 9, 2024

About this blog

Motivation

Disclaimer

Some motivations and disclaimers

Marian Klose

Dec 5, 2024

Categories

MTX Risk Calculator: my PharmacoFlash at IATDMCT 2026

Practical foundations for agentic workflows in pharmacometrics

Building a Human-in-the-Loop LLM Agent Workflow for Pharmacometrics

Using ChatGPT from the command line

Reproducing NONMEM’s MAP estimation in R

My attempt to understand the NLME estimation algorithm behind NONMEM

Expressing RUV as $THETA in NONMEM

About this blog